Endocrine Abstracts

IntroductionMaturity Onset Diabetes of the Young (MODY) type 1 is characterized by mutations in hepatocyte nuclear factor 4a (HNF4a) gene, leading to progressive dysfunction of pancreatic beta-cells with optimal response to sulphonylurea treatment. However, most of these patients are initially misdiagnosed as having type 1 diabetes and inappropriately treated with insulin. Data on adequate transferring from insulin to sulphonylureas following gen...

Background and aims: Maternal BMI and weight gain are associated with maternal and fetal complications in gestational diabetes (GD), but their relative contribution is not clearly defined. Our aim was to determine the influence of BMI and weight gain in the evolution of GD.Material and methods: Multicenter, retrospective study of women diagnosed with GD at the medical centers of the Portuguese Group for the Study of Diabetes and Pregnancy in 2011. We use...

Background: The Cushing’s disease (CD) is associated with comorbidities that have a significant impact on patients’ quality of life. However, it is not known the true impact of the disease remission on these comorbidities.Objectives: To assess the evolution of comorbidities associated with CD, after its remission.Methods: It was done an observational, analytical and retrospective study of patients with CD in remission, fo...

Introduction: Hyperosmolar hyperglycaemic state (HHS) and diabetic ketoacidosis (DKA) are the two most serious acute metabolic complication of diabetes mellitus (DM). The authors propose to characterise the admissions for HHS and DKA at a univeristy hospital.Methods: An observational, descriptive, and retrospective study in adults admitted to the hospital between January 2009 and October 2013 due to HHS and DKA. The information was accessed via the patie...

Introduction: Diabetes mellitus (DM) is a major risk factor for stroke and has been shown that diabetic patients who suffer stroke have a worse prognosis, with greater morbidity and mortality.Objectives: Determination of the prevalence of DM in hospitalised patients for ischaemic stroke. Comparison of demographic variables, complications prevalence, length of hospital stay and in-hospital mortality among diabetic and non-diabetic patients. Assessment of ...

Introduction: Primary hyperaldosteronism (PA) is a disturbance caused by the autonomous production of aldosterone by the adrenal gland. The most frequent causes are due to bilateral supra-renal gland hyperplasia and aldesterone producing adenoma. It is most frequent amongst women aged between 30 and 50 years of age. It is clinically characterised by hypertension (HTN), resistant to therapy. Hypokalaemia, which is known as a ‘classical marker’ is found in less than a ...

Background: The adrenal incidentalomas (AI), adrenal masses ≥10 mm in diameter incidentally detected, have increased their prevalence due to technological advances in imaging. The adrenalectomy is indicated in functioning adrenal tumors and in cases suspected of malignancy.Objectives: To analyze the characteristics of patients with AI and to evaluate the clinical outcome, in terms of evolution toward hypersecretion and significant growth, during fo...

Background: Community acquired pneumonia (CAP) is a common condition and a major cause of morbidity. Diabetes mellitus (DM) increases the risk and complications of infectious diseases. However, it is necessary to clarify if DM and glycemia at the time of presentation are prognostic factors in patients with CAP.Objectives: To evaluate the relationship between DM/glycemia at the time of presentation and complications, length of stay and mortality in patien...

Primary Aldosteronism (PA) is the most prevalent cause of secondary hypertension. The aim of this work was to characterize the diagnostic workup, treatment and follow-up of confirmed PA.The adrenal tumour study group of the Portuguese Society of Endocrinology undertook the first retrospective multicentre study of Portuguese PA patients. Data was gathered from nine Portuguese Endocrinology centres (three in the north, one in the centre and five in the sou...

Background: Residual C-peptide (CP) secretion has been associated with better glycemic control in patients with type 1 diabetes (T1D).Aim: To evaluate how residual fasting CP (fCP) secretion impacts glycemic control in T1D and to identify possible confounding factors.Methods: A retrospective analysis of adult patients with T1D followed in our department that had their fCP and glucose levels obtained on the same blood sample during ...